I use the full page layout for Americana and my other comics. My pages are 960x1280 in res. I like the full page over the panels since you can play around a lot more with composition. A hard action panel can be half a page while slow chatty panels can be small 1/8th size panels. One suggestion would be to take a look at some manga pages and look at their layouts. Some of them can be very effective. The layout is actually an important part of a comic. The old Batman serials in the newspaper were all the same 3 panels making the stories quite boring even though the action was hot. Liberty is an awesome comic but the panel idea doesn't work well for me. Some story elements need large panels while others need small ones. One method I saw was to thumbnail all the panels and show a low res page. When the user clicked on the panel, the high res version came up. This allowed perusing the comic very fast since the thumbnails were small then you could click on a particular panel to get a full screen shot.