Well, I replied to this on the Comics forum here, but... 1) I forgot to mention Hat Check Kelly (sorry, don't have a URL, but I'm sure it's linked to something already mentioned here...) - that uses a very innovative style with no frame borders. Sometimes its confusing and can be jarring, but it works. 2) I still say the best way is to combine these ideas. Create a set image size for each page, and use it as the story/scene dictates - either a single "splash page" or a standard "nine panel" page or some hybrid. Either that or research all the other online comics, and copy the style that looks most functional/appealing to YOU. If your reader's don't like it, they'll probably tell you; if they do they probably won't unless you ask!