Been using it about 6 weeks or so now, I'm reasonably happy with it, lots of stuff running in the background with it and still feeling my way as to what I can or can't switch off.
Poser 6 and 7 are running fine on it and so is Vue6Inf and CS3.
I have an issue with tool tips not showing in Vue but I can't say what is causing that at this time!
Overall I don't find Vista that much different to XP once you switch some of the more superfluous things off like the side bar for instance, totally unneccesary bit of dross IMO!

Injustice will be avenged.
Cofiwch Dryweryn.