One way to do it is to totally uproot and re-organize the things.

I have (literally) nothing in the program's internal runtime (for 5 or 6, or D|S).

I split 'em this way:

-old-stuff (holds V3, V2, V1, Milkids, Luke/Laura, Sp3, Mike 1/2/3, AD/MD, and anything built before 2005 - it weighs in at 46 GB).

• V4 Runtime (you guessed it - vicky 4 and her stuff... clothes, poses, MATs, things like that).

• A3 Runtime (same, but with A3)

• 3rd-party (Kururu, Terai Yuki, and meshes which weren't made by DAZ, or IMHO will ever have enough specific stuff to make into a separate runtime)

• Common (holds stuff like furniture, vehicles, weapons, all kinds of non-specific props, light sets, etc etc).

As a bonus, the proggies load up faster, and I can keep at least some sort of lid on organizing things. It also makes things scalable, portable, and pretty useful.

/P