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You could do a whole film without textures and as a z-toon. Almost all my commercial work with Poser was done that way. It may not be a powerfull enough app for CGI realism but look at South Park! That was done with construction paper cut outs!

Well, to be fair, only the pilot episode and some of the earlier stuff, before it actually became the South Park we know today,  was done that way. All other episodes, including those produced up to this point, were done using Autodesk (formerly Alias) Maya, and Corel software.

http://www.gazette.uwo.ca/article.cfm?section=Arts&articleID=1811

"Parker and Stone abandoned their cutouts and replaced them with industry-standard animation tools, most notably CorelDraw and Maya. The change in technique allowed for quicker production of episodes, to which Stone likened the process as “building a sandcastle with a bulldozer.”"

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Tools :  3dsmax 2015, Daz Studio 4.6, PoserPro 2012, Blender v2.74

System: Pentium QuadCore i7, under Win 8, GeForce GTX 780 / 2GB GPU.