I'm using P7 on Vista, but initially there were problems, which have been resolved by updating all my drivers, and the vista updates themselves. I've also had P5 installed for a short time and had no problems with it. But first recommmendation would to be to update all your drivers, especially for video. Also, when doing your poser install, have it Run As Administrator to install.

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Consider me insane if you wish, but is your reality any better?