I'm running Poser 7 on a dual core Vista 64 bit system (CPU Intel 6850) and it runs both faster and will handle larger more complex scenes than I got with a comparable 32 bit environment. So far the other 32 apps seem to run without a hitch as well. Part of the advantage of running 32 bit apps in a 64 bit environment is that you get more of the address space devoted to application code because the elements of the kernel can be run outside of the 32 bit VM leaving more address space for your app. The second core is also very helpful with the muti-threaded Poser 7 render engine.