IMO a mod can only do so much to fix some of the fundamental problems in the UI.

Take posing for instance, why after so many years are we still being forced to hunt and rotate a bunch of clumsy dials to get anything done ? At the very least we should have those rotate/move/scale gizmos every other app on the planet does. Even better would be some of the cooler facial control stuff from games like oblivion, where you just drag your mouse on various parts of the face and it automatically selects the correct morphs to use.

Add to this better ways to select things, change their properties, better integration of the various 'rooms', more ways to organize and sort your scene and renders (groups, passes, layers all come to mind) etc and we would maybe get a poser that belongs in this century.