I stopped using the PS native sharpening options... as some site's have their own embedded optimizing scripts which 9/10 play havoc with your images, as Im under the impression they use some sort of Bilinear sharpening script when re-sizing... which means it usually gets sharpened twice... the end product looks like you took the shot using a mobile phone :(
So I inevitably use Noise Ninja PS plugin to smoothe and sharpen if neccesary... this way, whatever you use the image for, whether its uploading or printing, the end results are completely satisfactory...

"If toast
always lands butter-side down, and cats always land on their feet, what
happens if you strap toast on the back of a cat and drop it?"

Steven Wright