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Vista is a pain in the ASS!

It's not once you get it running properly!!

Security settings is just one part of the story where Vista is concerned, first thing is, have you installed all the microsoft updates for Vista?
Even if you have switched UAC off, it's not enough, and neither is running in admin mode. Vista needs to have the folder permissions set right also!
Go into your Poser main folder and check that you have "full permissions" set, but also do this for the runtime folder too, sometimes Vista gives full paermission on the Poser folder but not on the runtime, so check those first!!

Injustice will be avenged.
Cofiwch Dryweryn.