As mentioned, it will run fine in Vista. As long as you keep things tidy for the most part. I suggest getting a good file shredder and use that to eliminate files and not the usual recycle bin. The recycle bin dies NOT delete the file, it just makes that space free to 'write over'. A shredder completely deletes the file with no traces and frees up the disc space with no 'ghost' file left-overs.