Any place where you have the polygons of the figure "compress" the polygons of the cloth, the cloth simulation will have problems.  Since this is only an approximation of real world behavior, basically the points of the mesh that are being squeezed between the two intersecting body parts will "squirt" away from the intersection.  In the real world when you bring your arms down to your sides, the cloth of your shirt is simply compressed between your inner arm and you torso.  In 3D software (not just poser), every vertex goes mad trying to find a safe place to settle that is at least as far as the minimum collision depth you have set.  If bodyparts actually intersect, as will often happen when you bring any figure's arms completely down, there IS no safe place anywhere near the intersection, so the vertices squirt out in all directions. 

re: your situation, examine the poses in every frame and look for any bodyparts that intersect other bodyparts.  Another alternative is to constrain the problem areas so they stop simulating once they hit their first collision.

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