I only use "save for web" if I'm creating an avatar or some other piece that requires a gif format. Instead, I'll resize within my main image file and save it out as a "file name.jpg", with a compression setting of 8, then decline to save the changes to the main image.

"Save for web" just does too much havoc for my tastes.

docandraider.com -- the collected cartoons of Doc and Raider