It is surely something related to your configuration of Vista
I recently buy a new computer and ask to the store to install Vista 64 bits (Sp1 included) and 8 gig ram I am running as administrator
I have  reinstalled  VUE6 infinite from  my original on a d:vue 6 infinite folder and installed the last update on it
After i have put lots of my stuff bought and modified  from my older folder of Vue (recalled Exxx Vue6 infinite) to the new installation
Everything  seems working good now
Good luck