Can't speak for Vista - I use XP x64 - All these work fine:

Poser7, V6I & V5I, Shade8, Hexagon, Silo, MS Office 2007 Suite, MS Money, Quicken, Quickbooks, Incredimail, PSP9, PS7, Modo302, Nero7, GeoCOntrol, WorldMachine, Carrara Pro 5 & 6 both work, Zbrush3, Blacksmith3d, P3dO Exlporer, Mailwasher, Xfrog, Google Earth & WorldWind, Kodak Easy Share, WinAmp, Realplayer & Uvmapper Pro(older version), Acronis 10 & Retrospect7(backups & ghosting) AVG 8, Winzip & WinRar, Wardrobe Wizard.

All my plugs worked for PSP except KPT1 which had a 16bit installer.

Edited: Bryce 6 & DS work although I have since deleted them due to non use.