I have mine heavily organized into folders with some characters having their own runtimes, but  I do clean out unused items frequently.

I have a box of nothing but 3D backup Cds it's frightening since most of the CDs the past 4-5 years are not of Free items, well gifts but not freebie offerings.

I startup Poser about 7am in the morning and head off for my coffee while everything loads up, most times I don't close the program until 10 pm, though if it lags a lot I'll shut down and restart it.

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I do not feel obliged to believe that the same God who has endowed us with sense, reason, and intellect has intended us to forgo their use.
-Galileo