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Have a look at the attached link. Those building are Poser scaled, and Poser handles this beautifully. You can do really large scenes in Poser, not as large as Vue though, and the only real limit is the polygon count.

Poser can handle a total scene polygon count of up to about one million polygons on my machine, so the scene should aim for about 100 000 maximum, so that you can still load props, vehicles, characters, clothing, weapons, etc.

Remember that a fully dressed and armed Poser character can easily reach 200 000 polygons, so two or three characters already take your scene to 600 000 polygons, add a few props, a vehicle, etc, and you quickly run out of memeory or slow the rendering down to an unacceptable level.

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