I would look at tasks active by running the system monitor . Anything running in background will affect Poser. Check swapfile(virtual memory ) and make sure enough is being allocated . If you have sufficient disk just switch it to system managed . Then look later and see how much is being used.

Do a defrag in safe mode , you will get a better result, and remember to defrag any disk drives on the system .

you might want to get correct referance , it was a freebie , and make sure your file referances are correct. If poser starts searching thats going to slow things down a lot .