I have run Vue 6 Pro Studio under Vista 32 bit without problems. I am now running V6Infinite under Vista 64 bit, also no problems, with installation and running. 

The more memory, the better - Vista is a memory hog! (I imagine you are going for a 32-bit system, so get 2GB memory if you can- although Vista 64-bit allows you to seriously party in the memory stakes) .

I will reiterate what Peggy says - follow her directions above and remember to run Vue under Vista as administrator - even if you are logged on as the administrator. If you don't, it will be a frustrating experience - speaking from personal experience here!

My Vista experience has actually been a very pleasurable one. I like Vista and I enjoy using it!