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Which version of Wine do you have? And can you describe what you've done to make it run better? I've still got a few issues with it, like when you select the head, for instance, the red outline stays on the features even when you mouse away from the preview window, making it more difficult to do fine control of ...say... the eyes.
Cheers, mate...

Most recent Wine version (1.0) with Ubuntu 8.04 and NVidia restricted graphics drivers.
In an earlier post in this thread I posted some few things I had to do to get it working.

That red selection marquee is really one of the things I was not yet able to resolve. However it's only a minor nuisance for me since a quick click on the camera roll-ball (or whatever it's official name is) makes the selection marquee go away until re-selected.

My experiences so far are very good with Poser/Wine after the initial fuss. I've also spent quite some time with it now and had a total of 0 crashes so far (something that wasn't the case in Windows). Python scripts and rendering speeds are faster than in Windows XP and posing for polygon-heavy models is about the same speed as in WinXP. Hierarchy window works much slower for me than in WinXP though. Poser Startup time is WAY faster with my 50Gb single Runtime ... probably due to Linux having superior disk file systems than Windows has (I'm running Poser on an ext3 file system). The good thing is that Wine is under heavy development so Poser will most likely ran better and better with each new version.