Now you've done it!! Cue the Anti Vista onslaught!!  Joking people!!

I'm using Vista Ultimate 64, I'm running Poser6 and 7, Vue6Infinite, Hexagon 2.5, Photoshop CS3.
I don't see any problems that I attribute to Vista but of course they could be but I don't think they are!!
Vue crashes occasionally but Vue is buggy anyway!

As for drives, I couldn't say, I had mine set up in the shop, 2 HD's in Raid 1 array [mirrored] to save loss of data if one dies!
If it was me, I'd wait for a shiny new one!!

Injustice will be avenged.
Cofiwch Dryweryn.