I got vista when it was first released on my desktop and used it for over 6 months and everything worked perfectly. This was when most of the issues in vista still existed, now they have release service pack 1 and most aplications are even supposed to work with it. However after getting my laptop some 5 months ago (moved to a new country without my dekstop) i have had a lot of problems with vista and 3d aplications.
Most games run fine but whenever i try to use poser and/or vue i keep getting crashes. Ive tried most fixes around but it still doesnt work well with poser at all.
Since im tired of having to spend 3 times the amount of time im supposed to on each image im going to throw vista out and get xp x64 and ubuntu on my second laptop.
I figured if i want fancy windows i might as well use ubuntu, and from what i have heard xp 64 seems to run both vue, poser and other 3d aplications perfectly.
So i guess it varies from computer to computer (drivers etc).
Just my 2 rather long cents....