I had Vista put on the computer I have had built for me. I can run Poser Pro, Carrara, Vue etc. just fine. Most of my issues with Vista are stupid things they did with it, which don't really affect any graphics stuff. I do know that my graphics driver crashes a LOT, and it's brand new (since my pc is like a month old) and says I have the most recent update. That is a major annoyance with me :-)

-Sarah