Recently a lot of folks have been seeing error messages similar to this, myself included. My suspicion is that a recent Windows update has made some changes to the way Poser is allowed to save its user preference files.

I am currently "waiting to see what happens" and hoping for a definitive answer from Smith Micro. Up until then I'm just closing the error message message and continuing with what I'm doing. I feel that if I guess at a solution, even though it may be a good guess, it may not right and could cause more harm than good.