Not sure about another entirely separate drive, but my main drive is divided into partitions,
and I keep all my graphics files on the D: partition, Vue, Poser, Paint Shop Pro, Daz Studio,
Wings 3d, Shade, etc..  Also I don't lump them all into a Programs File folder, each is
in the root folder, ie D:/Smith Micro for Poser.  I have hardly anything in the C: partition,
just Windows, so that I can periodically reformat the C: partition and then just
reinstall Windows without having to restore everything else to that partition.
(Windows get so much junk in it that after a while it gets too cranky and slow,
a reformat and reinstall makes it run better for a while.)
Been doing this for years and haven't had any problems with Poser.