Dunno if this will help, but I've had my textures on a back up drive once, then I moved them to my C: drive, after doing this and telling Poser where my textures were, sometimes if I have a card reader for my SD cards, for some reason it tries to search for the textures on it, even though it shows as an E: drive.  What's worse, it happens if I have my MP3 player hooked up and will even cause Windows to freeze when it boots until I unhook and reboot.

Poser would just sit there and never load anything, just act like it was searching, then if it did do something, it would bring up the typical Windows "can't read disk" error and neither "abort", "cancel", or "retry" would do anything until I unplugged the offending drive.

I also had a problem of having my textures backed up on my second drive with the exact same name as the one on C: and Poser would hang, for some reason it wants to search the backup drive and my thumb drives for EVERYTHING until I either unplug the drives or rename the directories.

It's a real pain in the @$$ :P