Thats the thing, I was thinking of Rendering each frame to a .BMP or .TIFF or .PNG some kind of Loseless format, and than edit and assemble into video using video editing software like Sony Vegas Video.

So its important to set the Resolution / Frame Rate right from the get go.

Example DVD would limit me to 720x480 29.97FPS NTSC or 720x488 25FPS (PAL)

I can also go the High Definition route and release a PC Watchably only format of 1920x1080 at 30FPS.
 
I'm probably over thinking this, but since doing the animation and rendering itself is such a long process, that I dont want to have to re-do or backtrack half way through the project.