Well, I can think of no better starting place for optimizing poser scenes for Vue than Linda's extremely helpful tips: http://www.cornucopia3d.com/forum/viewtopic.php?t=1541

These tips have been the BEST savers of my sanity (and my scenes) when importing Poser scenes to Vue. One thing I found particularly helpful was Linda's tip about ungrouping your Poser file and immediately regrouping it. This will most likely help you successfully save your scene as a VOB.

Also, the last post on this page -- http://www.cornucopia3d.com/forum/viewtopic.php?t=4125

gives tips about optimizing poser textures for Vue before importing the scene (smaller texture file sizes = less strain on Vue!)  :P Poser has a built in python script that can export ALL the textures in a given scene; and many different graphic programs have a function that allows you to optimize them all at once. ;)

Please write back if you have any more difficulties.  :  )

P.S. Even with my "large" Poser scenes, I don't "Create separate Poser files for each figure", as is mentioned in the 1st link. But ungrouping & regrouping my figures & props has helped me immensely... ;)