You should have no problems regardless of the hardware configuration you ultimately decide on. The only thing you have to do is tell Poser to "Render in a Separate Process" and increase the number of threads to match the number of cores your CPU has. Though Poser 7 doesn't officially support Vista because it was released prior to Vista, it will work fine in Vista x64 and will take advantage of multiple cores. However, the Firefly render engine in Poser 7 is still 32-bit and can only address up to 4GB of memory as a result. Poser Pro 7.0.3 is the first version to take advantage of 64-bit architecture. Not only can it address more than 4GB of memory, it also makes use of 64-bit instructions and will render faster as a result. Oddly enough though, the main Poser executable (even in Poser Pro) is still single threaded and doesn't run any faster on multicore systems, so always uses the "Render as Separate Process" setting or you won't benefit from having a multicore processor.