Poser 4 (and later) will run from a CD or a USB flash if needed. I've done both several times. I've even tried it from an SD card. Works fine!

And all versions run just fine in Vista. At least the 32 bit Vista, I haven't tried the 64 bit version.

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You just can't put the words "Poserites" and "happy" in the same sentence - didn't you know that? LaurieA
  Using Poser since 2002. Currently at Version 11.1 - Win 10.