The total number of  vertices and polygon count will effect the program but scale doesnt matter.

The amount of detail that will show would depend on your resolution . That is if you adjust the camera to show the entire building and do a pic say 320 x 240 you will see less detail than in a pic 3200 x 2400 and that is regardless of the model scale.

Note here: the model coordinates for a vertex may be 7 decimal places. If your scale is very small you may get into issues about the number of decimal points available to fit a new vertex between two others.