My suggestion would be to just edit your LibraryPrefs.xml file, changing the drive letter for your external runtime folder from E: to S: .

This file is in your user profile, in the same place as your Poser preferences (.ini) file. Look for the lines starting with <ContentFolder folder=.... and ending with  .....index="n" >

Don't change the index="0" or index="1" lines. Go to the index="2" line and change the drive letter you see there in the folder name. I can't show a real example because I'm on a Mac, and the paths are different, but it should look something like this:-

......

<ContentFolder folder="C:Program FilesPoser ProRuntimelibraries"  index="0" >
......

<ContentFolder folder="C:Program FilesPoser ProDownloadsRuntimelibraries"  index="1" >

......

<ContentFolder folder="E:3D LibrariesMain LibraryRuntimeLibraries"  index="2" >
......

"If I were a shadow, I know I wouldn't like to be half of what I should be."
Mr Otsuka, the old black tomcat in Kafka on the Shore (Haruki Murakami)