As far as I understand NoScript is a Firefox plugin, so it should not interfere with other programs outside firefox. If you close Firefox, you also close NoScript.

I run XP Pro Sp3 and I only use the default firewall (I am behind a router that does NAT) and Avira.

The library works fine (except for some crashes when I tried to update a folder after I copied something now in there). I also like the fact that it now orders stuff regardless of upper and lower case letters. Yes, the thumbs could be bigger (it would also help if they get bigger onmouseover).