I'm using SreeD with a wireframe preview window. Otherwise I'll get a crash every 2 mins. My video driver is the latest, I tried that as well. And funny that it doesnt really matter what I have open. I usually have 3d studio and Photoshop, plus iTunes + windows mail + some IMs and a few Internet Explorers. But they dont slow down or make my Poser crash more or less. I've tried closing everything.