You can point DS to your Poser runtime.

Your Poser lights are useless in DS
Some of your materials may be useless.
mc6s that you access from the material room would need to be converted, but MAT poses are fine.
You can't use Python scripts.
Or your Poser dynamic clothes.
You need a free plugin to inject PMD morphs.

Maybe forgot something

It's not the tool used, it's the tool using it