I am also starting work on a comic and have some samples that I played around a bit with in the galleries to get opinions on the style.  But here's one thing I have only thought of since then.
Most screens are wider than they are long.  But comic pages are the opposite shape.  And yet if you were to make a comic wide and not so high then it would be hard to follow it across I think as we all are used to looking from top down really.
What to other's think about panel layout on computers?
Love esther

MY ONLINE COMIC IS NOW LIVE

I aim to update it about once a month.  Oh, and it's free!