I'm at about 80 gigs and had the same problem.

My own solution was brute force. I started over.  

I first sorted my poser item install files into the various runtimes I wanted to create, then used the 3D Content Installer ]http://market.renderosity.com/mod/bcs/index.php?ViewProduct=61876&keyword=installer
to create the runtimes. Once I had everything sorted, it took just a few hours to create the runtimes, and that was walk-away time included. This is about as close to automatic as it gets, and creates a good, clean runtime.