Just install Poser in a NON DEFAULT location and Bob's your uncle. Installing anything in Vista under Program Files is asking for problems. Install Poser to C:3D... or whatever drive you have available (substitute the 3D for anything you'd like of course)

Also consider disabling UAC - it's more bother than help IMO.

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You just can't put the words "Poserites" and "happy" in the same sentence - didn't you know that? LaurieA
  Using Poser since 2002. Currently at Version 11.1 - Win 10.