Yes, don't, for any reason, copy your runtimes to a new location!  :)  This will save you hours of headaches!  Just do your normal runtime setup by going to 
Edit>Preferences>Directories>DAZ Studio Formats and click on Add and point it to your content.
TO find your poser content, do the same, but when it gets to the drop down in Directories, use Poser Formats and hit Search.  :)

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Knowledge is knowing a tomato is a fruit. Wisdom is not putting it into a fruit salad.