Philywebrider - I had the same problem with nothing on the paint tab working. Actually the 2d brushes would work until I switched to a 3d brush, then after that neither the 2d nor 3d would work.  I have an Intuos 3 on Windows 7 64-bit. Before narrowing my problem down to a conflict with the Wacom and the gigaware usb mouse (standard mouse, nothing fancy, from Radioshack) I updated all drivers (nvidia, wacom) and Vue (I'm running build 47776).

It's a pity I couldn't solve the problem without disconnecting the usb mouse, because I liked it better than the wacom mouse - it's more responsive. I did submit a ticket to eon, but I've not heard anything back.

Really it appears it was more of a driver/hardware problem on my setup than a Vue problem anyway. It doesn't seem to be a common problem. You're the first person I've some across with something similar. Good luck on getting 3d sculpting to work, it's a nice feature.