A lot of the problems seem to be very individual in nature.  People have their librarys in different places which creates a uniqueness to the environment.
I've been going over things with Smith MIcro.  I'm not getting a failure or an error message.  In my case and because of the environmental items, it may be very personal, turning off indexing seems to have had at least some possitive effect.
IN my case it's now reading the runtime that it starts up with but  ot always reading any that I switch to.