I use a Wacom Intuos 3. XP64. It's the small one too. Fits the way I draw. I use it with all my main apps. Vue8.4I, Modo, PSP, Painter and so on. But I use it only for the brush work. I still find the mouse easier to use for the main work. I find it hard to constantly be clicking the pen when doing things. Could be these old hands.

Plus I find the mouse easier when combining the keyboard hot keys.

So it's an individual choice as to how you use it.