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Is there anything that speaks against blender besides the interface issue? 

Not that I know of. :)   To the plus side of that, they are apparently working on a new interface too, to alleviate a lot of the difficulties people have with it. Which includes myself. :) I found Wings more intuitive and approachable.. But I do take my Wings models into other programs when I need to do certain operations that it doesn't do so well.  But all of my clothes in the marketplace and in freestuff is done 95% in Wings.

It really comes down to your own preference, with interface, features, workflow and whatnot.. I don't think there's a perfect 3d modeller.. There are tons of them, ranging from free to shareware priced to wicked expensive.. Sure, a lot of professionals I know use Maya which is super powerful, but has a rough learning curve too..

I'm just a jolly hobby artist, so do take what I say with a bucket of salt. :)