You'd only  notice a benefit rendering single frames, if you're rendering a very heavy scene, and you close Poser and everything possibly close-able and just have the queue manager open to render, as it does not need Poser to be open in order to render.
The benefit would lie in having the queue manager as much free memory to render as possible.
Of course, this is a specific case where there would be a difference, but for pretty much all the time, there won't be a difference.

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