Pretty much any program of any complexity takes time to learn, and if you have already learned habits in a different app that has a similar purpose, those skills really get in the way of learning the new app.  I gave up on trying to use more than a couple of tools and became way more productive once I decided to just do as much of the work as possible in a single app - for me, Cinema 4D, but pretty much any app will do once you learn it well.  It's good to have as many needed features as possible built into the same app, for modeling, UVmapping, texturing, grouping and maybe morph target design for some projects.

Just things like interface differences can really make you burn a lot of extra brain power, especially when the interface is wildly different from other apps like Blender or Zbrush are.  Both are very powerful tools, but learning their interfaces is a major project all on its own and that effort is completely non-transferrable because they have such unique interfaces.

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