Not necessarily. If the calculations fail it's generally a sign that something is wrong with the obj (OR that there is major intersections going on at frame 1 - and you've outruled that already)  And that's not your fault but may be due to how it's modelled.

What exactly is it you're trying to clothify? :)

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You just can't put the words "Poserites" and "happy" in the same sentence - didn't you know that? LaurieA
  Using Poser since 2002. Currently at Version 11.1 - Win 10.