It will be no consolation to you, but this behavior doesn't happen with the Mac version of PP2010.

If you want to start with an empty scene when you start up Poser, delete Andy and make any other changes in lighting, cameras, preview window, etc. that you want to see every time. Then go into Preferences and set it to Launch to Preferred State (instead of Factory State). Then click the Set Preferred State button. Now it will launch with all the settings you made to the scene.