Comic life has a few quirks, but it is the best solution I've seen.  The ability to establish templates, drag and drop and especially the movable, sizable balloons make this vastly preferable to using any 2d editing software to create comics.  Spend the few extra bucks for the upgraded version - you get a lot more pre-designed formats and fonts.

If you use it, pay attention to the dpi you intend to output and the pixel size of your images - this is where people get disappointed with the results, essentially creating images with low resolution and then expecting comic life to resize them in an acceptable fashion.

Klebnor

Lotus 123 ~ S-Render ~ OS/2 WARP ~ IBM 8088 / 4.77 Mhz ~ Hercules Ultima graphics, Hitachi 10 MB HDD, 64K RAM, 12 in diagonal CRT Monitor (16 colors / 60 Hz refresh rate), 240 Watt PS, Dual 1.44 MB Floppies, 2 button mouse input device.  Beige horizontal case.  I don't display my unit.