Aside from basic 'system' stuff, I never put anything into the Programs folder on the C: drive.

If the option is availble to you, I'd recommend having a partition, preferably on a separate HD, dedicated to programs, including Poser.

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Windows 10 x64 Pro - Intel Xeon E5450 @ 3.00GHz (x2)

PoserPro 11 - Units: Metres

Adobe CC 2017