I've always had Poser in it's own partition and never had a problem after scrubbing the windows partiton when re-installing. Only thing you'll have to do is put your shortcuts in the start menu/ desktop and recreate any file associations. Also moved to bigger HDs the same way.

Poser 11 , 180Gb in 8 Runtimes, PaintShop Pro 9
Windows 7 64 bit, Avast AV, Comodo Firewall
Intel Q9550 Quad Core cpu,  16Gb RAM, 250Gb + 250Gb +160Gb HD, GeForce GTX 1060